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NanoMixer

Description: Laboratory Microfluidics Mixer for mRNA/DNA lipid/polycation nanoparticle preparation (max. pressure 200 psi)
Catalog Number: NanoMixer
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NanoMixer User Manual
NanoMixer User Manual
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  • Type:
    NanoMixer NanoMixer-Triplex NanoMixer-Quad
  • Syringe Inlet:
    0.5mL×2 1.0mL×2 2.5mL×2 5.0mL×2 10mL×2
  • Microfluidic Chip Mixing Type:
    Y-type S-type X-type
  • Microfluidic Chip Channel:
    A+B=AB A+B+C=ABC (Triplex) A+B+C+D=ABCD (Quad)
  • Microfluidic Chip Temperature control:
    None Heating/cooling jacket with built-in temperature sensor
  • Voltage:
    110V 220V
  • Warranty:
    Standard 1 year 2 year 3 year 4 year 5 year
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  • Description
  • How to Use
  • FAQs and Tips
  • How to Order
NanoMixer Microfluidic Mixing System:
 
NanoMixer is a precision microfluidic mixing platform designed for laboratory-scale preparation of mRNA, DNA, and siRNA delivery systems. It is an electrically driven, benchtop instrument that operates without the need for compressed air or hydraulic oil. The NanoMixer enables programmable flow rates (0–10 mL/min per pump) and controlled mixing ratios using gastight syringes (1 mL, 2.5 mL, 5 mL, or 10 mL), with configurations available for dual (NanoMixer), triple (NanoMixer-Triplex), or quadruple (NanoMixer-Quad) component blending.
Each NanoMixer model is equipped with independent syringe pumps, a PLC control system, and mixing modules that ensure reproducible and uniform formulation. With a working pressure up to 200 psi and temperature tolerance up to 80°C, the system supports sterile, dead-volume-minimized mixing suitable for sensitive biopharmaceutical applications.
 
Applications of NanoMixer Microfluidic Mixer:
 
mRNA/DNA/siRNA delivery formulations
Nanoemulsions and liposomes
Fat emulsions
Cell disruption and nanoparticle suspensions
Multi-component formulation development
 
Performance Features of NanoMixer:
 
Precision Mixing: Programmable ratio and speed control with ±0.1 mL inlet accuracy
Modular Design: Available in 2, 3, or 4-pump configurations for dual, ternary, or quaternary blending (A+B, A+B+C, A+B+C+D). The quaternary pump configuration also supports continuous microfluidic blending of A+B by allocating two pumps for continuous feeding of component A and two pumps for component B.
Compact and Lightweight: Integrated design (36×41×48 cm, 16 kg) suitable for benchtop use
Thermal Tolerance: Up to 80°C (176°F) for formulation stability
Digital Interface: Pressure display or analog pressure gauge options
Easy Cleaning: Flush-to-clean system
Compliant: CE and RoHS certified
 
Specifications
Catalog No. NanoMixer NanoMixer-Triplex NanoMixer-Quad
Flow Rate 0-20mL/min 0-20mL/min 0-20mL/min
Min. Sample 0.5mL 0.5mL 0.5mL
Max. Pressure 200psi
A+B=AB		 200psi
A+B=AB+C=ABC		 200psi
A+B=AB
A+B+C=ABC
A+B+C+D=ABCD
Dimensions(cm) 36 × 41 × 48 46 × 41 × 48 56 × 41 × 48
Weight 16 kg (35 lbs) 20 kg (44 lbs) 25 kg (55 lbs)
Working Temp. 4 - 80ºC (176ºF)
Power 110V/220V
Cleaning Flush to clean
Application mRNA/DNA/siRNA delivery systems, Nano emulsion, fat emulsion, liposome, cell disruption, nano dispersion, microsphere
Features Digital display of pressure, flow rate and temperature
Standard Features
Channel Y-type Microfluidic Mixing Chip  AB-Y; ABC-Y; ABCD-Y
Control System High pressure programming control systems: touch screen, speed control, auto stop control by volume, time, pressure or temperature, settable volume control as low as 0.2mL, display of flow rate and time, overload protection
Pressure Sensor Flush membrane pressure sensor, digital display on the touch screen, 
Inlet Type UNF 1/4-28
Outlet Type UNF 1/4-28
Inlet Reservoir 1mL gas tight syringe
Product Material 316L stainless steel, viton, teflon, PEEK, tempered glass
Material Standard Sanitary grade, FDA, GMP
Warranty 1 year against any manufacturing defects
Option Features
Channel NanoMixer Y-type (Single Line) Microfluidic chip: AB-Y; AB-YT;
NanoMixer S-type (Single strand like RNA) Microfluidic chip: AB-S; AB-ST;
NanoMixer X-type (Duplex strand like RNA) Microfluidic chip: AB-X; AB-XT;
NanoMixer-Triplex Y-type (Single Line) Microfluidic chip: ABC-Y; ABC-YT;
NanoMixer-Triplex S-type (Single strand like RNA) Microfluidic chip: ABC-S; ABC-ST;
NanoMixer-Triplex X-type (Duplex strand like RNA) Microfluidic chip: ABC-X; ABC-XT;
NanoMixer-Quad Y-type (Single Line) Microfluidic chip: ABCD-Y; ABCD-YT;
NanoMixer-Quad S-type (Single strand like RNA) Microfluidic chip: ABCD-S; ABCD-ST;
NanoMixer-Quad X-type (Duplex strand like RNA) Microfluidic chip: ABCD-X; ABCD-XT;
T: Heating/cooling jacket with built-in temperature sensor; 
Control System Please send the drawing if you need customized Microfluidic Chip
Inlet Reservoir 2.5mL, 5mL, 10mL gas tight syringe
Online Monitoring Electron Microcope
Product Introduction and User Guide Video Sharing:

NanoMixer Introduction

Types of Microfluidic Chip Channels
Genizer NanoMixer -Microfluidic Chip Microchannels
 

 




How to replace the Microfluidic Chip
 
Step Operation
1 Loosen the PEEK split conical connector counterclockwise and separate it from the chip body.

 
 
2 Loosen the temperature sensor counterclockwise and detach it from the chip body.


 
3 Remove the chip module from the bracket (if connected to a water bath temperature control system, disconnect the silicone tubing from the barb fitting first).
4 Use a hex key to unscrew the four fastening screws, remove the top cover and tempered glass plate, and place them gently on a clean surface.
5 Take out the new microfluidic chip and gently wipe the channel surface with a lint-free paper moistened with ethanol to ensure it is clean and free of residue.
6 Take out the nanomixer seal membrane from the accessories, peel off the protective film, align it centrally on the chip, and press out any trapped air.
7 Replace the tempered glass plate and top cover in order, and tighten the four fastening screws.
8 Reattach and tighten the temperature sensor and PEEK split conical connector in their original positions.
9 Pre-flush the chip with pure water and check for leaks.
10 After confirming there are no issues, the chip is ready for normal use.

 
Troubleshooting:

Mechanical Faults

1.Backflow at Inlet
Symptom: Liquid flows back at the inlet while the syringe is in the extrusion stroke.
Cause: The inlet check valve has failed.
Solution: Replace the check valve.

2. Backflow at Outlet
Symptom: Liquid flows back at the outlet while the syringe is in the suction stroke.
Cause: The outlet check valve has failed.
Solution: Replace the check valve.

3. Microfluidic Chip Microchannel Blockage
Symptom: Sudden rise in internal system pressure causes connected capillaries to detach due to high pressure.
Cause: The microchannels on the chip surface are blocked.
Solution: Clean the chip microchannels.

4. Insufficient Suction Due to Air in Tubing
Symptom: The syringe does not fully fill, and air is present in the liquid.
Cause: Air is trapped inside the tubing system.
Solution: To degas the system, push the liquid upward in the syringe while loosening the outlet check valve to release trapped air.
Once the liquid flows steadily, tighten the valve, and repeat this process two to three times until all air is expelled.
 
Electrical Faults

1.Red Power Switch (PWR) Not Lit
1) Check if the fuse is blown; replace if necessary.
2) Check the device power connection; reconnect if faulty.
3) Check the wall socket; ensure the plug is fully inserted.

2. Clicking “Start” on the Main Interface Has No Response
1) Turn off the power and wait 30 seconds before restarting.
2) The system will rebuild, which takes a few seconds.
If the problem persists after restarting, contact after-sales service for assistance.

Equipment Maintenance

1. Repair and Preventive Maintenance
The required frequency of repair and preventive maintenance depends
on usage and the specific applications performed.
It is generally recommended to schedule maintenance and preventive
servicing at least once per year. Adhere to the recommended maintenance intervals.
If any component fails, it is recommended to replace it immediately to
prevent further damage to the system. Following these guidelines will help maximize the system’s service life.
 
2 Daily Cleaning
The syringe holder and chip bracket are the most common areas for spills, droplets, and material buildup. Surfaces can be wiped with ethanol or isopropanol. If fluid flows along the syringe holder into the interior of the instrument, there is no need to stop the machine during operation because the system is designed with a dry-wet separation; small amounts of liquid will not affect safety. After stopping the instrument, wipe the area with a clean, lint-free cloth. If fluid splashes onto the plastic housing, wipe it promptly to keep the exterior dry and avoid damage to the paint.
 
To clean the instrument body, cover, and all internal components, wipe surfaces with any of the following:
a. Warm water with a mild, non-abrasive detergent
b. Ethanol
c. Isopropanol

Use a soft cloth to wipe the surfaces, avoiding scratches that could affect the appearance of the instrument.

 
1. Order the unit from your local agent (recommended)

2. Add the item to the cart, get an online quote from our website and confirm the order and payment accordingly (recommended and quick)
get the quote and Pay offline

3. Email us to get a quote

4. Order and pay online from the website if the total amount is under $2,500.00.