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Jacketed Liposome Extruder

Description: The Genizer Jacketed Liposome Extruder is compressed air-driven and temperature-controlled, from testing to manufacturing production of liposome and lipopolyplex, for drug and gene delivery.
Catalog Number: Cat.GJE
Price:
USD
$4,000.00   Login for Discount
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Liposome_Extruder_English
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  • Catalog No.:
    GJE-10mL GJE-100mL GJE-800mL GJE-3000mL GJE-10000mL
  • Gas Connection:
    CGA580 (USA) G5/8 (UK, CN) DIN477 (GE) NF E 29-650/C (FR) UNI4409 (IT)
  • Warranty:
    Standard 1 year 2 year 3 year 4 year 5 year
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  • Description
  • How to Use
  • FAQ
Specifications
Description:
 
The Genizer Jacketed Liposome Extruders is compressed air-driven and temperature-controlled, from testing to manufacturing production of liposome and lipopolyplex, for drug and gene delivery. Homogeneous samples can be produced quickly and easily in minutes; typically 5-10 passes are sufficient to produce a sample with uniform liposome size. Genizer Jacketed Liposome Extruders are designed to generate homogeneous unilamellar liposomes and Lipopolyplex. Extrusion is a one-step procedure that produces liposomes by forcing lipid suspensions of drug, protein or gene through track-etched filters of defined pore size. The process is relatively gentle, exposing the formulation to moderate pressures up to 500 psi at controlled temperatures. The Genizer Jacketed Extruder offers virtually no dead-volume, is easy to clean, suitable for sterilization and in compliance with FDA and GMP sanitary standards in pharmaceuticals.
 
Application:
 
Liposome extrusion
 
Performance:
 
No dead volume
The Jacketed Extruder can control the temperature of the extrusion
 
Specifications
Catalog No. GJE-10mL GJE-100mL GJE-800mL GJE-3000mL GJE-10000mL
Sample Size 10 mL 100 mL 800 mL 3,000 mL 10,000 mL
Cooling Jacketed Jacketed Jacketed Jacketed Jacketed
Dimensions 13 cm×23 cm×25 cm 20 cm×23 cm×32 cm 18 cm×22 cm×35 cm 27 cm×32 cm×52 cm 43 cm×52 cm×70 cm
Weight 4 kg 7 kg 19 kg 45 kg 155kg
Min. Sample Size 1 mL 5 mL 20 mL 60 mL 150 mL
Max. Pressure 500 psi 500 psi 800 psi 800 psi 800 psi
Max. Temp. 80 ºC (176 ºF)
Power Type Inert gas (e.g., nitrogen or argon) used with a 5–12 MPa gas cylinder and pressure regulator
Cleaning Disassemble, rinse, clean, and dry
Sterilization Whole unit autoclavable
 
Standard Features
Parts  Liposome Jacketed Extruder
316L Stainless Steel Filter Plate Microporous Plate
+ Large-Pore Plate (φ25)		 Microporous Plate
+ Large-Pore Plate (φ47)		 Sintered Plate
(20um φ90)		 Sintered Plate
(20um φ142)		 Sintered Plate
(20um φ293)
Drain Disc Sold separately
Liposome Membrane Sold separately
Nitrogen Tubing G5/8" - 14 TPI BSP inlet nitrogen high pressure soft tubing (1 m, 1.5 m)
Pressure Regulator Adapter 3/8MNPT&1/4 F Flare
Outlet Type Luer Type
Product Material 316L stainless steel, NBR
Material Standard Sanitary grade; compliant with FDA and GMP sanitary standards
 
Option Features
Detector Pressure gauge for pressure regulator, pressure transducer, temperature transducer
Liposome Membrane φ25 (30, 50, 80, 200, 400, 800nm, 1um, 2μm, 5μm, 10μm) φ47 (30, 50, 80, 200, 400, 800nm, 1um, 2μm, 5μm, 10μm) φ90 (30, 50, 80, 200, 400, 800nm, 1um, 2μm, 5μm,10μm) φ142 (30, 50, 80, 200, 400, 800nm, 1um, 2μm, 5μm, 10μm) φ293 (30, 50, 80, 200, 400, 800nm, 1um, 2μm, 5μm, 10μm)
Sintered Plate No No φ90 (5μm, 10μm, 20μm) φ142 (5μm, 10μm, 20μm) φ293 (5μm, 10μm, 20μm)
O-ring NBR；FKM；FFKM
Nitrogen Tubing 2 m, 2.5 m, 3 m
Loading Tool No 500 mL, 1 L, 3 L feed cups; peristaltic pump
CIP/SIP Customizable (not compatible with drain disc)
Outlet Type Customizable barbed type
 
Product Introduction and User Guide Video Sharing:
Introduction of Jacketed Liposome Extruder
1) The Jacketed Liposome Extruder uses compressed air such as nitrogen (N2) as the pressure source.

The Jacketed Liposome Extruder uses compressed air such as nitrogen (N2) as the pressure source.
1. Add liposome membrane
2. Add the liposome crude sample from the inlet
3. Connect gas connection with regulator
4. Open the nitrogen and pressure the liposome crude sample through the membrane

2) Please select the suitable gas connection for your nitrogen cylinder
CGA580  (USA) United States
G5/8  (UK,CN) United Kingdom, China
DIN477 (GE) Germany
NF E 29-650/C (FR) France
UNI4409 (IT) Italy

adaptor with 3/8-inch male NPT and 1/4-inch female flare outlet
Recommend Uniweld RHP400 Nitrogen Regulator
https://www.amazon.com/Uniweld-RHP400-Nitrogen-Regulator-Connection/dp/B008HQ6GXO?ref_=ast_bbp_dp

3) Warning
Warning
1) Always use regulator, which can be obtained from your gas supplier.
2) Before opening the extruder, be sure to shut down the gas and open the relief valve.
3) DO NOT point the inlet of the liposome extruder at any person or object, as this could pose a safety risk or result in property damage.
4) The user must be responsible in the case of any violation of this clause and recommendation, as well as any other unsafe practices.

 
1. Liposomal Extrusion System for Jacketed Liposome Extruders. 



2. What is the drain disc?

The drain disc is made using PETE material and is used together with the filter membrane to avoid "pore blinding" or the obstruction of the capillary pores in screen membranes, which results in increased flow rates and throughputs.



3. Jacketed Liposome Extruders connected with chiller(circulator) for samples cooling or constant temp.

BTUs depends on temp desired and any other factor for the liposomesbeing extruded.