APPLICATIONS
Biotechnology

Genizer high pressure homogenizer technology is widely used in biotechnology and biopharmaceutical applications for cell disruption, nanoemulsion preparation, liposome and nanoparticle formulation, and biopharmaceutical product development.

Key Advantages of Genizer High Pressure Homogenizer • Precise and controllable particle size reduction for nano-scale processing
• High reproducibility and process consistency in high pressure homogenization
• Scalable high pressure homogenizer systems from lab to industrial production
• Suitable for a wide range of biological and biopharmaceutical materials
• Continuous and efficient high pressure homogenization processing
Cell Disruption (Process Optimization) Cell disruption efficiency using a high pressure homogenizer depends on pressure level and cell type. Proper parameter selection ensures optimal performance and product integrity. The table below summarizes recommended operating parameters for various biological samples.
Pressure and chamber selection for various applications with NanoGenizer
Cells Mammalian cell 
Mammalian cell		     Insect cell
Insect cell		 Bacteria cell
Bacteria cell		 Yeast cell
Yeast cell		 Algae cell
Algae cell		 Spore
Spore
Sample CHO | Hela Sf9 | Sf21 | H5 E. Coli Yeast Green algae Ganoderma
Pressure 600-800bar
8500-11500psi		 600-1000bar
8500-14500psi		 800-1000bar
11500-14500psi		 1200-1400bar
17500-20000psi		 1200-1500bar
17500-21500psi		 1300-1600bar
18500-23000psi
Chamber H10Z, H10Z-RT H10Z, H10Z-RT H10Z, H10Z-RT H10Z, H10Z-RT H10Z, H10Z-RT H10Z, H10Z-RT

When used with an RT interaction chamber, biological activity of sensitive materials can be better preserved during processing. The RT interaction chamber structure is shown below.

Figure 1. RT Interaction chamber structure
Contact Genizer for Processing Solutions Need help selecting the right equipment or optimizing your process? Contact Genizer to discuss your application or request a demo.
Email: info@genizer.com
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