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High pressure homogenization process pumps are able to deliver 100-300 MPa hydrostatic pressure to a liquid before any restriction to flow is imposed, regardless of the flow rate. Current industrial, pilot, and lab-scale high pressure homogenizers are equipped with plunger-like pumps and valves, or nozzles, or chambers made from abrasion-resistant ceramics or hard gemstones. There are mainly three traits that characterize effective homogenization: cavitation (FIG. A), impact (FIG. B), and shear. The valves, nozzles, or chambers possess one or a combination of these traits. (Adapted from http://web.utk.edu/~fede/high pressure homogenization.html)

Selection Guide for Chamber Types

Type of Chamber Application Disadvantage
Y-Type Chamber (FIG. C) Suitable for Pharmaceutical emulsion Blockage Tendency for high viscosity liquid or suspension
Impact Valve (FIG. B) Between A and C Between A and C
Cavitation Nozzle (FIG. A) Suitable for high viscosity liquid, suspension or paste Tendency of breaking in Pharmaceutical emulsion
Internal Disks Illustration of Flow Cross-Sectional Diagram

Y-Type Chamber made by two blocks of optically flat disk

The Y-Type Interaction Chamber (FIG. C), regarded as one of the most powerful chambers to date, has been used by several manufacturers, including Microfluidics (Y-Type Interaction Chamber), Avestin (Static Homogenizing Valve) and Nanomizer (Collision-Type Generator). In these systems, the flow stream is split into two channels that are redirected over the same plane at right angles and propelled into a single flow stream. High pressure promotes a high speed at the crossover of the two flows, which results in high shear, turbulence, and cavitation over the single outbound flow stream.

The Y-Type Chamber is generally made of two blocks of diamond or ceramic with a very small opening (nozzle) of Φ50~400μm. Two block-forming members are first ground and lapped to be optically flat, and then grooves corresponding to the desired sizes and shapes are etched into the face of each block in a precisely aligned manner.Homogenization energy is concentrated at the collision point where the liquid streams collide in the internal drain. (Adapted from www.nanomizer.co.jp)

Internal Disks Illustration of Flow Cross-Sectional Diagram

Y-Type Chamber made by two blocks of optically flat disk

We have been providing high quality Y-Type Diamond Interaction Chambers for high pressure homogenization in compliance with FDA sanitary standards. The Y-Type Single-Slotted Chamber F12Y-1 and F20Y-1 can be used as a full replacement for the chambers used on M-110Y, M-110P, M-110L, M-110S, and M-110EH Microfluidizers, and the Static Homogenizing Valve from Avestin. The Y-Type Multi-Slotted Chamber can be used as a full replacement for the chambers used on production units, such as M-210, M-7115, M-7125 and M-7250. Our confidence in the quality of our products lets us provide a 1-year warranty, compared to the 90-day warranty of other manufacturers.

The HT-0.5ml Hand Drive Testing High Pressure Homogenizer was developed in response to customer demand for better equipment to test various high pressure processing nanotechnology with applications in the pharmaceutical, biotechnology, chemical, nutraceutical, food, cosmetic and energy industries. Researchers with limited budget and resources are able to test a wide variety of homogenizing technologies on the market, but only our patent processor, can provide the benefits of stable nanoemulsions and challenging cell disruption even for high-viscosity liquid or solid suspension.